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J Med Virol. 2019 Apr;91(4):717-721. doi: 10.1002/jmv.25346. Epub 2018 Nov 8.

Identification of hepatitis B virus genotype I in Thailand.

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Abbott Laboratories, Infectious Disease Research, Abbott Park, Illinois.
University of California San Francisco, San Francisco, California.


The rare hepatitis B virus genotype I (HBV-I) classification includes complex A/G/C/U recombinants identified amongst the individuals from China, India, Laos, and Vietnam. Herein we report the first HBV-I specimen from Thailand, with detectable HBsAg despite a 10-amino-acid truncation. This HBV-I genome has a similar recombinant pattern to reference strains, including a C region that branches basal to references, suggesting a premodern era recombination event gave rise to HBV-I. With an average sequence divergence from other genotypes ranging from 7.66% (standard deviation [SD], 0.42%; C) to 14.27% (SD, 0.31%; H), this new genome supports the HBV-I classification as a unique genotype.


hepatitis B virus; recombinant virus; recombination; virus classification

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