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J Cell Biochem. 2018 Oct 22. doi: 10.1002/jcb.27335. [Epub ahead of print]

Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1.

Author information

1
Department of Obstetrics and Gynecology, Xiangya Hospital of Central South University, Changsha, Hunan, China.
2
Department of Pathology, Xiangya Hospital of Central South University, Changsha, Hunan, China.

Abstract

Cervical cancer (CC) is one of the most common female malignancies, and resveratrol is a polyphenol isolated from the skins of grapes, which has been reported to significantly alter the cellular physiology of tumor cells. However, little is known about the role of phospholipid scramblase 1 (PLSCR1) in pathogenesis of CC. Here, we demonstrated that resveratrol could significantly inhibit both the growth of HeLa cells and expression of PLSCR1. These results suggest that resveratrol-mediated cell growth inhibition can be regulated by PLSCR1.

KEYWORDS:

cervical cancer; phospholipid scramblase 1 (PLSCR1); resveratrol

PMID:
30350320
DOI:
10.1002/jcb.27335

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