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Psychopharmacology (Berl). 2019 Feb;236(2):581-590. doi: 10.1007/s00213-018-5083-5. Epub 2018 Oct 22.

Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [18F]fallypride PET.

Author information

1
Department of Psychology, PMB 407817, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN, 37240-7817, USA. christopher.t.smith@vanderbilt.edu.
2
Department of Psychology, PMB 407817, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN, 37240-7817, USA.
3
Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Ave South, Suite 3057, Nashville, TN, 37212, USA.
4
Department of Radiology and Radiological Sciences, Medical Center North, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN, 37232, USA.
5
Department of Radiology, UAB School of Medicine, 1802 6th Ave South, Birmingham, AL, 35233, USA.
6
Department of Psychology and Neuroscience, Duke University, 417 Chapel Drive, Durham, NC, 27708, USA.

Abstract

RATIONALE:

Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed.

OBJECTIVES:

Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine administration.

METHODS:

We used [18F]fallypride positron emission tomography (PET) to measure the change in dopamine D2/3 receptor availability (%ΔBPND, an index of dopamine release) between placebo and D-amphetamine sessions in two independent datasets containing a total of 39 females (on either hormonal birth control n = 18, postmenopausal n = 10, or studied in the first 10 days of their menstrual cycle n = 11) and 37 males.

RESULTS:

Using both a priori anatomical regions of interest based on previous findings and voxelwise analyses, we failed to consistently detect broad sex differences in D-amphetamine-induced dopamine release. Nevertheless, there was limited evidence for greater right ventral striatal dopamine release in young adult males relative to similarly aged females, but this was not consistently observed across samples. Plasma estradiol did not correlate with dopamine release and this measure did not differ in females on and off hormonal birth control.

CONCLUSIONS:

While our finding in young adults from one dataset of greater %ΔBPND in males is partially consistent with a previously published study on sex differences in D-amphetamine-induced dopamine release, our data do not support the presence of consistent widespread sex differences in this measure of dopamine release.

KEYWORDS:

(up to 10): Sex differences; D-amphetamine; D2/3 receptor availability; Dopamine; Dopamine release; PET

PMID:
30350220
PMCID:
PMC6401232
[Available on 2020-02-01]
DOI:
10.1007/s00213-018-5083-5

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