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Int J Environ Res Public Health. 2018 Oct 19;15(10). pii: E2301. doi: 10.3390/ijerph15102301.

Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle.

Author information

1
Department of Kinesiology, Inha University, Incheon 22212, Korea. gjwnsdnjs03@naver.com.
2
Department of Kinesiology, Inha University, Incheon 22212, Korea. susie_737@naver.com.
3
Department of Kinesiology, Inha University, Incheon 22212, Korea. 77nodaji@hanmail.net.
4
Department of Kinesiology, Inha University, Incheon 22212, Korea. dparkosu@inha.ac.kr.
5
Department of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon 22212, Korea. johykang@inha.ac.kr.
6
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea. twkim0806@naver.com.
7
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea. changju@khu.ac.kr.
8
National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea. sdy925@gmail.com.
9
National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea. phyhanj@gmail.com.
10
Department of Kinesiology, Hannam University, Daejeon 34430, Korea. yoonjh@hannam.ac.kr.
11
Department of Leisure Sports, Seoil University, Seoul 02192, Korea. sujeenj@nate.com.
12
Department of Kinesiology, Inha University, Incheon 22212, Korea. kwakhb@inha.ac.kr.

Abstract

Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator of skeletal muscle remodeling and apoptosis. However, the effects of exercise on skeletal muscle remodeling and mitochondria-mediated apoptosis in obese skeletal muscles have not been clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), control plus exercise (CON + EX), high-fat diet (HFD), and HFD plus exercise groups (HFD + EX). After obesity was induced by 20 weeks of 60% HFD feeding, treadmill exercise was performed for 12 weeks. Exercise ameliorated the obesity-induced increase in extramyocyte space and a decrease in the cross-sectional area of the skeletal muscle. In addition, it protected against increases in mitochondria-mediated apoptosis in obese skeletal muscles. These results suggest that exercise as a protective intervention plays an important role in regulating skeletal muscle structure and apoptosis in obese skeletal muscles.

KEYWORDS:

apoptosis; exercise; mitochondria; obesity; skeletal muscle

PMID:
30347719
PMCID:
PMC6210945
DOI:
10.3390/ijerph15102301
[Indexed for MEDLINE]
Free PMC Article

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