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Eur Neurol. 2018;80(1-2):106-114. doi: 10.1159/000493530. Epub 2018 Oct 22.

Medication Adherence of Statin Users after Acute Ischemic Stroke.

Author information

1
Department of Neurology, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
2
Department of Neurology, Seoul National University Hospital, Seoul, Republic of Koreabwyoon@snu.ac.kr.
3
Department of Neurology, Gil Medical Center, Gachon University, College of Medicine, Incheon, Republic of Korea.
4
Department of Neurology, Chonbuk National University Medical School and Hospital, Jeonju, Republic of Korea.
5
Department of Neurology, Konkuk University Medical Center and Konkuk University School of Medicine, Seoul, Republic of Korea.
6
Department of Neurology, Inje University Sanggye Paik Hospital, Seoul, Republic of Korea.
7
Department of Neurology, Eulji General Hospital, Seoul, Republic of Korea.
8
Department of Neurology, Kosin University Gospel Hospita, Busan, Republic of Korea.
9
Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
10
Department of Neurology, Inje University Busan Paik Hospital, Busan, Republic of Korea.
11
Department of Neurology, Catholic University of Daegu, School of Medicine, Daegu, Republic of Korea.
12
Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.
13
Department of Neurology, Changwon Fatima Hospital, Changwons, Republic of Korea.
14
Department of Neurology, Korea University Guro Hospital, Seoul, Republic of Korea.
15
Department of Neurology, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea.
16
Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
17
Department of Neurology, Chungnam National University Hospital, Daejeon, Republic of Korea.
18
Division of Movement Disorder, Department of Neurology, Konyang University College of Medicine, Daejeon, Republic of Korea.
19
Department of Neurology and Cerebrovascular Center, Kyungpook National University School of Medicine and Hospital, Daegu, Republic of Korea.
20
Outcomes Research/Real World Data Team, Corporate Affairs/Health and Value Division, Pfizer Pharmaceutical Korea Limited, Seoul, Republic of Korea.

Abstract

Although statins are established therapy for the secondary prevention of ischemic stroke, factors associated with adherence to statin treatment following ischemic stroke are not well known. To address this, we assessed the 6-month statin adherence using 8-item Morisky Medication Adherence Scale-8 in patients with acute ischemic stroke. Of 991 patients, 65.6% were adherent to statin at 6-month after discharge. Multiple logistic regression analysis showed that patients' awareness of hyperlipidemia (OR 1.62; 95% CI 1.07-2.43), large artery stroke subtype (versus non-large artery stroke, OR 1.79; 95% CI 1.19-2.68), and alcohol drinking habits (OR 1.64; 95% CI 1.06-2.53) were positively associated, while high statin dose (versus low dose, OR 0.6; 95% CI 0.40-0.90) and higher daily number of medication pills (OR 0.93; 95% CI 0.88-0.97) were found to have a negative association with self-reported good adherence to statin medication after acute ischemic stroke. However, stroke severity and diagnosis of hyperlipidemia were not associated with adherence. These results suggest that educational and motivational interventions may enhance statin adherence because modifiable factors were associated with statin adherence.

KEYWORDS:

Acute ischemic stroke; Patient-reported outcomes; Quality of life; Statin adherence

PMID:
30347393
DOI:
10.1159/000493530
[Indexed for MEDLINE]

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