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Cancer Epidemiol. 2018 Dec;57:85-89. doi: 10.1016/j.canep.2018.10.008. Epub 2018 Oct 19.

Trends in cervical cancer mortality rates in Lithuania, 1987-2016.

Author information

1
Laboratory of Cancer Epidemiology, National Cancer Institute, Baublio 3B, LT-08406 Vilnius, Lithuania. Electronic address: ruta.everatt@nvi.lt.
2
Department of Gynaecologic Oncology, National Cancer Institute, Vilnius, Lithuania.

Abstract

BACKGROUND:

The aim of this study was to investigate time trends in cervical cancer mortality rates in Lithuania across age groups and time periods over a 30-year time span.

METHODS:

Data on numbers of deaths from cervical cancer during the period 1987-2016 were obtained from the WHO mortality database. Trends in age-standardised mortality rates (ASR, world standard), and age-specific rates were analysed by calculating annual percentage change (APC) using Joinpoint regression. In addition, age-period-cohort analysis was performed.

RESULTS:

Joinpoint regression analysis indicated that mortality from cervical cancer increased by 2.0% (95% CI: 1.2, 2.9) annually from 1987 to 2002 and decreased by 2.3% (95% CI: 3.2, 1.3) annually thereafter. In age groups 20-39 and 40-49 years after a sharp increase by 5.6% (95% CI: 2.6, 8.7) and 5.9% (95% CI: 2.7, 9.2), respectively, mortality rates declined since around 2000 with slopes of -4.8% (95% CI: -7.6, -1.9) and -2.7% (95% CI: -4.7, -0.6), respectively. Among women aged 50-59 years there was an increase in mortality (APC = 2.6%; 95% CI: 0.8, 4.5) followed by decrease with a not statistically significant slope (APC = -2.2%; 95% CI: -5.1, 0.7) since 2004. For older women mortality rates moderately declined during the entire time span. The age-period-cohort analysis suggests that temporal trends in cervical cancer mortality rates could be attributed to period and cohort effects.

CONCLUSIONS:

Opportunistic screening may have contributed to favourable recent changes in cervical cancer mortality rates in Lithuania, however not to the extent seen in most European countries.

KEYWORDS:

Cervical cancer; Lithuania; Mortality; Screening; Trends

PMID:
30347336
DOI:
10.1016/j.canep.2018.10.008
[Indexed for MEDLINE]

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