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FEMS Microbiol Lett. 2018 Nov 1;365(22). doi: 10.1093/femsle/fny256.

Cross-reactivity of latex agglutination assay complicates the identification of Burkholderia pseudomallei from soil.

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Center of Excellence Research for Melioidosis (CERM), Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand.
Equine Research Institute, Microbiology Division; 1400-4 Shiba, Shimotsuke, Tochigi 3290412, Japan.
Department of Infectious Diseases and Immunology, College of Veterinary Medicine, and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32608, USA.


The monoclonal antibody-based latex agglutination tests targeting a high molecular weight exopolysaccharide antigen of Burkholderia pseudomallei are commercially available. The tests are primarily used in routine diagnosis of melioidosis in major hospitals in Thailand and some endemic countries. Being a rapid test, this technique was employed as a presumptive test to identify colonies of B. pseudomallei among many others grown from soil specimens collected from southern Thailand. Cross-reactivity of these tests with other soil bacteria was a concern since it complicated the identification of B. pseudomallei. Here, we describe the cross-reactivity of two commercial latex agglutination tests for melioidosis with B. territorii, B. pseudomultivorans, B. multivorans and B. cenocepacia isolates from soil.


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