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Elife. 2018 Oct 22;7. pii: e40039. doi: 10.7554/eLife.40039.

A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility.

Li H1,2, Wang H1,2, Jing M1,2, Zhu J1,2, Guo B1,2, Wang Y1,2, Lin Y1,2, Chen H1,2, Kong L1,2, Ma Z1,2, Wang Y1,2, Ye W1,2, Dong S1,2, Tyler B3,4, Wang Y1,2.

Author information

1
Department of Plant Pathology, Nanjing Agriculture University, Nanjing, China.
2
Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, China.
3
Center for Genome Research and Biocomputing, Oregon State University, Corvallis, United States.
4
Department of Botany and Plant Pathology, Oregon State University, Corvallis, United States.

Abstract

Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for full virulence on soybean and binds to a novel soybean transacetylase, GmTAP1, in vivo and in vitro. PsAvh52 could cause GmTAP1 to relocate into the nucleus where GmTAP1 could acetylate histones H2A and H3 during early infection, thereby promoting susceptibility to P. sojae. In the absence of PsAvh52, GmTAP1 remained confined to the cytoplasm and did not modify plant susceptibility. These results demonstrate that GmTAP1 is a susceptibility factor that is hijacked by PsAvh52 in order to promote epigenetic modifications that enhance the susceptibility of soybean to P. sojae infection.

KEYWORDS:

Glycine max; Phytophthora sojae; epigenetic modifications; histone acetylation; infectious disease; microbiology; nuclear re-localization; plant biology; plant susceptibility

PMID:
30346270
PMCID:
PMC6249003
DOI:
10.7554/eLife.40039
[Indexed for MEDLINE]
Free PMC Article

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