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Clin Exp Ophthalmol. 2018 Oct 21. doi: 10.1111/ceo.13419. [Epub ahead of print]

Intracameral antibiotics for prophylaxis of postoperative endophthalmitis in Australia: a review.

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Department of Ophthalmology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Centres for Ophthalmology & Visual Science, University of Western Australia, Perth, Western Australia, Australia.


Postoperative endophthalmitis is a severe complication which may result in loss of vision. Intracameral antibiotics have been shown to reduce the risk of this complication and are extensively used worldwide, with vancomycin, cefuroxime and moxifloxacin most commonly used. Choices in Australia are currently limited to vancomycin and cefazolin, since cefuroxime and moxifloxacin are not available. Vancomycin has been safely and effectively used in our department for more than two decades. Recent publications have risen concerns regarding the association of haemorrhagic occlusive retinal vasculitis a potentially blinding complication with intracameral vancomycin. This concern has driven us to review the safety and efficacy of currently available antibiotics in the context of Australian practice.


antibiotics; cataract surgery; endophthalmitis; ophthalmology publication; prophylaxis


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