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J Mol Neurosci. 2018 Dec;66(4):512-523. doi: 10.1007/s12031-018-1175-2. Epub 2018 Oct 22.

Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy.

Author information

1
Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China.
2
Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China.
3
Department of Interventional Radiology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.
4
Department of Endocrinology, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.
5
Department of Interventional Radiology, Shandong Medical Imaging Research Institute, Jinan, Shandong, China.
6
Department of Neurosurgery, Qingdao Hospital of Traditional Chinese Medicine, Qingdao, Shandong, China.
7
Department of Neurology, Qingdao Central Hospital, Qingdao, Shandong, China. boxuqdhc@126.com.
8
Department of Interventional Radiology, Jinan Military General Hospital, Shifan Road 25, Tianqiao District, Jinan, 250000, Shandong, China. gangsunqdhc@126.com.

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is characterized by the deposition of β-Amyloid (Aβ) plaques which contribute to its pathology. The present study was aimed at exploring the protective effects of euxanthone against Aβ-induced neurotoxicity both in vivo and in vitro. We found that euxanthone significantly attenuated Aβ1-42-induced memory and spatial learning dysfunction and also significantly reversed Aβ1-42-induced neuronal apoptosis and autophagy in the hippocampal region. Euxanthone also protected the neuroblastic PC12 cells against Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy. In conclusion, euxanthone exerts its neuroprotective effect against Aβ1-42 by inducing autophagy, indicating its potential therapeutic role in AD.

KEYWORDS:

Alzheimer’s disease; Autophagy; Euxanthone

PMID:
30345461
DOI:
10.1007/s12031-018-1175-2
[Indexed for MEDLINE]

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