Format

Send to

Choose Destination
Commun Biol. 2018 Oct 16;1:170. doi: 10.1038/s42003-018-0180-x. eCollection 2018.

Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities.

Author information

1
Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Munich, 81377 Germany.

Abstract

The internal organs embedded in the cavities are lined by an epithelial monolayer termed the mesothelium. The mesothelium is increasingly implicated in driving various internal organ pathologies, as many of the normal embryonic developmental pathways acting in mesothelial cells, such as those regulating epithelial-to-mesenchymal transition, also drive disease progression in adult life. Here, we summarize observations from different animal models and organ systems that collectively point toward a central role of epithelial-to-mesenchymal transition in driving tissue fibrosis, acute scarring, and cancer metastasis. Thus, drugs targeting pathways of mesothelium's transition may have broad therapeutic benefits in patients suffering from these diseases.

Conflict of interest statement

The authors declare no competing interests.

Publication type

Publication type

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center