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Version 1. Wellcome Open Res. 2018 Aug 7;3:96. doi: 10.12688/wellcomeopenres.14696.1. eCollection 2018.

Daytime variation in hepatitis C virus replication kinetics following liver transplant.

Author information

1
Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, OX3 7AZ, UK.
2
Institute for Data Analytics, University of Leeds, Leeds, Yorkshire, UK.
3
Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, West Midlands, B15 2TT, UK.

Abstract

Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. Results: A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. Conclusions: These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation.

KEYWORDS:

Circadian rhythm; HCV; allograft; liver transplant; time of day; viral rebound

Conflict of interest statement

No competing interests were disclosed.

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