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Version 1. Wellcome Open Res. 2018 Aug 7;3:96. doi: 10.12688/wellcomeopenres.14696.1. eCollection 2018.

Daytime variation in hepatitis C virus replication kinetics following liver transplant.

Author information

Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, OX3 7AZ, UK.
Institute for Data Analytics, University of Leeds, Leeds, Yorkshire, UK.
Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, West Midlands, B15 2TT, UK.


Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. Results: A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. Conclusions: These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation.


Circadian rhythm; HCV; allograft; liver transplant; time of day; viral rebound

Conflict of interest statement

No competing interests were disclosed.

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