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Curr Opin Behav Sci. 2018 Oct;23:65-74. doi: 10.1016/j.cobeha.2018.03.011. Epub 2018 Apr 5.

Estradiol and hippocampal memory in female and male rodents.

Author information

1
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211.

Abstract

Estrogens influence nearly every aspect of hippocampal function, including memory formation. Although this research has traditionally focused on ovariectomized females, more recent work is providing insights into the ways in which estrogens regulate hippocampal function in both sexes. This review provides an overview of estrogenic regulation of hippocampal function in female and male rodents, with a particular emphasis on memory formation. Where applicable, we discuss the involvement of specific estrogen receptors and molecular mechanisms that mediate these effects. The review concludes by suggesting gaps in the literature that need to be filled to provide greater insights into potential sex differences in the effects of estrogens on hippocampal function.

KEYWORDS:

ERK; consolidation; estrogen; estrogen receptors; hippocampus; sex differences

PMID:
30345337
PMCID:
PMC6191066
[Available on 2019-10-01]
DOI:
10.1016/j.cobeha.2018.03.011

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