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Cancer Surv. 1986;5(3):573-83.

Oestradiol 16 alpha-hydroxylase: a risk marker for breast cancer.


17-oxidation and 2- and 16 alpha-hydroxylation of oestradiol show important correlations with biological aspects of breast cancer in women and mice. The presence of mouse mammary tumour virus may lead to increased 16 alpha-hydroxylation. 16 alpha-hydroxyoestrone (which may be generated in an autocrine manner) forms covalent linkages with amino groups on proteins and nucleotides.

[Indexed for MEDLINE]

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