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Cancer Sci. 2018 Oct 21. doi: 10.1111/cas.13838. [Epub ahead of print]

Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer proliferation by partly silencing p21 expression.

Ji H1,2, Hui B1,2, Wang J1,2, Zhu Y1,2, Tang L2,3, Peng P1,2, Wang T4, Wang L2,5, Xu S1,2, Li J1,2, Wang K1,2.

Author information

1
Department of Oncology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
2
The Second Clinical Medical College of Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
3
Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
4
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.
5
Department of Geriatrics, Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, People's Republic of China.

Abstract

Colorectal cancer (CRC) is the third most common malignant in the world, and long noncoding RNA (lncRNA) has become a new gene. Here, we report a novel lncRNA MAPKAPK5-AS1 which acts as a critical oncogene in the CRC. In addition, we attempted to explore the functions of MAPKAPK5-AS1 on tumor progression in vitro and in vivo. qRT-PCR was performed to examine the expression of MAPKAPK5-AS1 in CRC tissues and cells. MAPKAPK5-AS1 expression was significantly up-regulated in 50 colorectal cancer tissues and increased expression of MAPKAPK5-AS1 was found to be associated with greater tumor size and advanced pathological stages in CRC patients. Knockdown of MAPKAPK5-AS1 significantly inhibited proliferation and caused apoptosis in CRC cells. Then,we found that p21 is a target of MAPKAPK5-AS1. In addition, we first demonstrated that MAPKAPK5-AS1 plays a carcinogenic role in colorectal cancer. MAPKAPK5-AS1 is a novel prognostic biomarker and a potential therapeutic candidate for CRC cancer. This article is protected by copyright. All rights reserved.

KEYWORDS:

MAPKAPK5-AS1 colorectal cancer lncRNA Proliferation apoptosis

PMID:
30343528
DOI:
10.1111/cas.13838
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