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J Pediatr. 2019 Feb;205:277-280. doi: 10.1016/j.jpeds.2018.09.046. Epub 2018 Oct 17.

Umbilical Cord Tissue and Meconium May Not Be Equivalent for Confirming in Utero Substance Exposure.

Author information

1
Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN. Electronic address: jennifer.colby@vanderbilt.edu.
2
Enterprise Analytics, Vanderbilt University Medical Center, Nashville, TN.
3
Department of Pediatrics, Vanderbilt University, Nashville, TN.
4
Department of Pediatrics, Vanderbilt University, Nashville, TN; Department of Health Policy, Vanderbilt University, Nashville, TN; Vanderbilt Center for Child Health Policy, Nashville, TN.

Abstract

In a retrospective study of 501 neonates with potential in utero substance exposure, the drug detection performance of a commercially available umbilical cord tissue toxicology test was evaluated against a commercially available gold standard meconium toxicology test. Drugs detected in paired meconium and umbilical cord tissue samples were often discordant.

KEYWORDS:

drug screening; in utero drug exposure; meconium; toxicology; umbilical cord tissue

PMID:
30342870
PMCID:
PMC6348119
[Available on 2020-02-01]
DOI:
10.1016/j.jpeds.2018.09.046

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