Screening and surveillance in hereditary gastrointestinal cancers: Recommendations from the European Society of Digestive Oncology (ESDO) expert discussion at the 20th European Society for Medical Oncology (ESMO)/World Congress on Gastrointestinal Cancer, Barcelona, June 2018

Eur J Cancer. 2018 Nov:104:91-103. doi: 10.1016/j.ejca.2018.09.004. Epub 2018 Oct 18.

Abstract

Patients with hereditary gastrointestinal (GI) cancers represent a substantial fraction of the overall affected population. Although awareness for hereditary GI cancer syndromes is on the rise, identification of patients and measures of surveillance are often unclear in everyday clinical routine. Therefore, the European Society of Digestive Oncology expert discussion 2018 at the World Congress on Gastrointestinal Cancer focussed on screening and surveillance of hereditary colorectal, gastric and pancreatic cancers. An international panel of experts and opinion leaders developed the here presented recommendations based on published evidence and on profound clinical expertise to facilitate clinical routine in identification and caretaking of patients with familial GI cancers.

Keywords: Familial pancreatic cancer; Hereditary GI cancer; Hereditary diffuse gastric cancer; Lynch syndrome; Polyposis; Screening; Surveillance.

Publication types

  • Consensus Development Conference
  • Practice Guideline

MeSH terms

  • Age of Onset
  • Chemoprevention
  • Colonoscopy
  • DNA Mutational Analysis
  • Early Detection of Cancer / methods
  • Early Detection of Cancer / standards*
  • Gastrointestinal Neoplasms / diagnosis
  • Gastrointestinal Neoplasms / epidemiology
  • Gastrointestinal Neoplasms / genetics*
  • Gastrointestinal Neoplasms / prevention & control
  • Genetic Counseling
  • Genetic Testing / standards
  • Germ-Line Mutation
  • Humans
  • Molecular Diagnostic Techniques / standards
  • Neoplastic Syndromes, Hereditary / diagnosis
  • Neoplastic Syndromes, Hereditary / epidemiology*
  • Oncogenes
  • Organ Specificity
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / epidemiology
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / prevention & control
  • Risk Assessment
  • Sequence Analysis, DNA / methods
  • Sequence Analysis, DNA / standards