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BMC Res Notes. 2018 Oct 19;11(1):744. doi: 10.1186/s13104-018-3858-8.

Nigella sativa as an anti-inflammatory agent in asthma.

Author information

1
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jalan Persahabatan Raya No.1, Rawamangun, Jakarta, 13230, Indonesia.
2
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine and Health Sciences Universitas Islam Negeri Syarif Hidayatullah, Jakarta, Indonesia.
3
Department of Pharmacology, Faculty of Medicine and Health Sciences Universitas Islam Negeri Syarif Hidayatullah, Jakarta, Indonesia.
4
Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
5
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jalan Persahabatan Raya No.1, Rawamangun, Jakarta, 13230, Indonesia. fariz.nurwidya@gmail.com.
6
Department of Nutrition, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. fariz.nurwidya@gmail.com.

Abstract

OBJECTIVE:

Nigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. The laboratory experiment was used to investigate the effectivity of N. sativa as an anti-inflammatory on mast cells. Six groups of mast cells were stimulated by C 48/80 to release histamine. Group 1 were without N. sativa, while group 2, 3, 4, 5, and 6 were given N. sativa with concentrations of 0.1 mg/ml, 0.2 mg/ml, 0.3 mg/ml, 0.4 mg/ml and 0.5 mg/ml, respectively. Histamine concentration was measured by high-performance liquid chromatography-fluorometry.

RESULT:

The study showed that N. sativa ethanol extract effectively inhibit histamine release from peritoneal Wistar rat mast cells proportionally to its concentration. N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. N. sativa could be considered as a potential therapy for asthma therapy and prevention.

KEYWORDS:

Anti-inflammatory; Asthma; Nigella sativa

PMID:
30340634
PMCID:
PMC6194640
DOI:
10.1186/s13104-018-3858-8
[Indexed for MEDLINE]
Free PMC Article

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