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Reprod Toxicol. 2018 Dec;82:88-93. doi: 10.1016/j.reprotox.2018.10.006. Epub 2018 Oct 16.

Comparison of congenital malformations among babies born after administration of letrozole or clomiphene citrate for infertility treatment in a Korean cohort.

Author information

1
Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea; Institute of Women's Life Medical Science, Seodaemun-gu, Seoul, Republic of Korea.
2
Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Gangnam-gu, Seoul, Republic of Korea.
3
Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Republic of Korea; Institute of Women's Life Medical Science, Seodaemun-gu, Seoul, Republic of Korea. Electronic address: garfieldzz@yuhs.ac.

Abstract

This retrospective study investigated and compared the incidence of congenital foetal anomalies after letrozole versus clomiphene citrate (CC) administration for infertility treatment. Data from 142 newborns were included: letrozole group, n = 83; CC group, n = 61. Congenital anomalies were found in 7.2% (6/83) patients in the letrozole group and 18.0% (11/61) patients in the CC group, with no significant between-group difference (p = .066). Major congenital anomaly rate was 2.4% (2/83) in the letrozole group and 3.3% (2/61) in the CC group, with no significant between-group difference (p > 0.999). There was no significant difference in major and minor congenital anomalies between the groups after excluding premature infants (birth at a gestational age of <37 weeks), low birth weight, and very low birth weight. The results of this study demonstrate the stability of letrozole compared to that of CC for infertility treatment in pregnant women.

KEYWORDS:

Clomiphene citrate; Congenital anomaly; Infertility treatment; Letrozole

PMID:
30339890
DOI:
10.1016/j.reprotox.2018.10.006
[Indexed for MEDLINE]

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