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Neurosci Lett. 2018 Nov 20;687:290-303. doi: 10.1016/j.neulet.2018.10.023. Epub 2018 Oct 15.

Temperature-dependent behaviors of parasitic helminths.

Author information

1
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
2
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: ehallem@ucla.edu.

Abstract

Parasitic helminth infections are the most common source of neglected tropical disease among impoverished global communities. Many helminths infect their hosts via an active, sensory-driven process in which environmentally motile infective larvae position themselves near potential hosts. For these helminths, host seeking and host invasion can be divided into several discrete behaviors that are regulated by both host-emitted and environmental sensory cues, including heat. Thermosensation is a critical sensory modality for helminths that infect warm-blooded hosts, driving multiple behaviors necessary for host seeking and host invasion. Furthermore, thermosensory cues influence the host-seeking behaviors of both helminths that parasitize endothermic hosts and helminths that parasitize insect hosts. Here, we discuss the role of thermosensation in guiding the host-seeking and host-infection behaviors of a diverse group of helminths, including mammalian-parasitic nematodes, entomopathogenic nematodes, and schistosomes. We also discuss the neural circuitry and molecular pathways that underlie thermosensory responses in these species.

KEYWORDS:

Host seeking; Parasitic helminth; Parasitic nematode; Schistosomes; Sensory behavior; Strongyloides; Thermosensation

PMID:
30336196
PMCID:
PMC6240462
[Available on 2019-11-20]
DOI:
10.1016/j.neulet.2018.10.023
[Indexed for MEDLINE]

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