Pathogen-based precision medicine for drug-resistant tuberculosis

Matthias I Gröschel; Timothy M Walker; Tjip S van der Werf; Christoph Lange; Stefan Niemann; Matthias Merker

doi:10.1371/journal.ppat.1007297

Pathogen-based precision medicine for drug-resistant tuberculosis

PLoS Pathog. 2018 Oct 18;14(10):e1007297. doi: 10.1371/journal.ppat.1007297. eCollection 2018 Oct.

Authors

Matthias I Gröschel^{1

2}, Timothy M Walker³, Tjip S van der Werf², Christoph Lange^{4

5

6

7}, Stefan Niemann^{1

7}, Matthias Merker¹

Affiliations

¹ Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
² Department of Pulmonary Diseases & Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³ Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
⁴ Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.
⁵ International Health / Infectious Diseases, University of Lübeck, Lübeck, Germany.
⁶ Department of Medicine, Karolinska Institute, Stockholm, Sweden.
⁷ German Center for Infection Research (DZIF) Tuberculosis Unit, Borstel, Germany.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / therapeutic use*
Humans
Mycobacterium tuberculosis / drug effects
Mycobacterium tuberculosis / genetics*
Patient Care Planning*
Precision Medicine*
Predictive Value of Tests
Tuberculosis, Multidrug-Resistant / drug therapy
Tuberculosis, Multidrug-Resistant / genetics*
Tuberculosis, Multidrug-Resistant / microbiology
Whole Genome Sequencing / methods*

Substances

Antitubercular Agents

Grants and funding

TMW is an NIHR Academic Clinical Lecturer. MM received partial funding through the Leibniz Science Campus Evolutionary Medicine of the Lung (EvoLung). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.