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Crit Rev Food Sci Nutr. 2018 Oct 18:1-9. doi: 10.1080/10408398.2018.1507996. [Epub ahead of print]

The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials.

Author information

1
a Health Policy Research Center, Institute of Health, Student Research Committee , Shiraz University of Medical Sciences , Shiraz , Iran.
2
b Food Security Research Center, Department of Community Nutrition School of Nutrition and Food Science , Isfahan University of Medical Sciences , Isfahan , Iran.
3
c Health Policy Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.
4
d Indigenous and Global Health Research, Department of Medicine , University of Alberta , Edmonton , Canada.
5
e Department of Community Nutrition School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences , Tehran , Iran.
6
f Health Information Management Research Center , Kashan University of Medical Sciences , Kashan , Iran.
7
g Department of Cardiology School of Medicine , Kashan University of Medical Sciences , Kashan , Iran.
8
h Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of caffeine intake on weight loss. We searched the following databases until November 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. We estimated an intake-status regression coefficient (Beta) for each primary study and estimated the overall pooled Beta and SE using random effects meta-analysis on a double-log scale. Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Thirteen RCTs with 606 participants were included in the meta-analyses. The overall pooled Beta for the effect of caffeine intake was 0.29 (95%CI: 0.19, 0.40; Q  =  124.5, I2 = 91.2%) for weigh, 0.23 (95%CI: 0.09, 0.36; Q  =  71.0, I2 = 93.0%) for BMI, and 0.36 (95% CI: 0.24, 0.48; Q  =  167.36, I2 = 94.0%) for fat mass. For every doubling in caffeine intake, the mean reduction in weight, BMI, and fat mass increased 2 Beta-fold (20.29  =  1.22, 20.23  =  1.17, and 20.36  =  1.28), which corresponding to 22, 17, and 28 percent, respectively. Overall, the current meta-analysis demonstrated that caffeine intake might promote weight, BMI and body fat reduction.

KEYWORDS:

Caffeine; meta-analysis; weight loss

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