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Medicine (Baltimore). 2018 Oct;97(42):e12898. doi: 10.1097/MD.0000000000012898.

Hormonal biomarkers for the noninvasive diagnosis of endometriosis: A protocol for a network meta-analysis of diagnostic test accuracy.

Author information

1
Department of Clinical Laboratory, Second Hospital of Lanzhou University.
2
Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University.
3
The Second Clinical Medical College of Lanzhou University.
4
Department of Nursing, Rehabilitation Center Hospital of Gansu Province, Lanzhou.
5
Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing.
6
Gansu Provincial Hospital.
7
Emergency Department, Rehabilitation Center Hospital of Gansu Province, Lanzhou, China.

Abstract

BACKGROUND:

Endometriosis is a major cause of disability and compromised the quality of life in women and teenage girls. The gold standard for diagnosis of endometriosis is laparoscopy with histology of excised endometriosis lesions. However, women can suffer for 8 to 12 years before obtaining a correct diagnosis. Several biomarkers showed good diagnostic value for endometriosis, but no studies directly or indirectly compare the diagnostic value of different biomarkers. We perform this network meta-analysis (NMA) to assess the diagnostic accuracy of hormonal biomarkers, and to find a most effective hormonal biomarker for the diagnosis of endometriosis.

METHODS:

A systematic search will be performed using PubMed, EMBASE, Cochrane Library and Chinese Biomedicine Literature to identify relevant studies from inception to August 2018. We will include random controlled trials, cross-sectional studies, case-control studies, and cohort studies that evaluated the diagnostic accuracy of hormonal markers for endometriosis. The Quality Assessment of Diagnostic Accuracy Studies 2 quality assessment tool will be used to assess the risk of bias in each study. Standard pairwise meta-analysis and NMA will be performed using STATA V.12.0, MetaDiSc 1.40 and R 3.4.1 software to compare the diagnostic efficacy of different hormonal biomarkers.

RESULTS:

The results of this study will be published in a peer-reviewed journal.

CONCLUSION:

This study will summarize the direct and indirect evidence to determine the diagnostic accuracy of the hormonal biomarkers for endometriosis and attempt to find a most effective biomarker for the diagnosis of endometriosis.

ETHICS AND DISSEMINATION:

Ethics approval and patient consent are not required as this study is a meta-analysis based on published studies.

PROSPERO REGISTRATION NUMBER:

CRD42018105126.

PMID:
30335017
PMCID:
PMC6211906
DOI:
10.1097/MD.0000000000012898
[Indexed for MEDLINE]
Free PMC Article

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