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Aging Cell. 2019 Feb;18(1):e12843. doi: 10.1111/acel.12843. Epub 2018 Oct 17.

Programmed longevity, youthspan, and juventology.

Longo VD1,2,3.

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University of Southern California, Los Angeles, California.
Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, California.
IFOM FIRC Institute of Molecular Oncology, Milan, Italy.


The identification of conserved genes and pathways that regulate lifespan but also healthspan has resulted in an improved understanding of the link between nutrients, signal transduction proteins, and aging but has also provided evidence for the existence of multiple "longevity programs," which are selected based on the availability of nutrients. Periodic fasting and other dietary restrictions can promote entry into a long-lasting longevity program characterized by cellular protection and optimal function but can also activate regenerative processes that lead to rejuvenation, which are independent of the aging rate preceding the restricted period. Thus, a "juventology"-based strategy can complement the traditional gerontology approach by focusing not on aging but on the longevity program affecting the life history period in which mortality is very low and organisms remain youthful, healthy, and fully functional.


Juventology; Longevity; aging; gerontology; healthspan; youthspan

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