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Lipids. 2018 Aug;53(8):797-807. doi: 10.1002/lipd.12087. Epub 2018 Oct 17.

ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers.

Author information

1
Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, 7-45-1, Nanakuma Jonan-ku, Fukuoka, 814-0180, Japan.
2
Division of Medical Safety Science, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kanagawa, 210-0821, Japan.
3
Université de Lille 2, CNRS, CHU Lille, Institut Pasteur de Lille, UMR 8199 - EGID, Pôle recherche, 1 place de Verdun, Lille, 59045 Cedex, France.
4
Department of Internal Medicine, Division of Preventive Medicine, Tenjin Clinic, 2-12-1, Tenjin, Chuou-ku, Fukuoka, Fukuoka, 810-0001, Japan.
5
Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Banchi Uehara, Nishihara-cho, Nakagami-gun, Okinawa, 9030215, Japan.
6
Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, 207 Banchi Uehara, Nishihara-cho, Nakagami-gun, Okinawa, 9030215, Japan.
7
Saitama City Institute of Health Science and Research, 7-5-12, Suzuya, Chuou-ku, Saitama, 338-0013, Japan.
8
Department of Genomics of Common Disease, School of Public Health, Imperial College, South Kensington Campus, London, SW7 2AZ, UK.

Abstract

It has been reported that polymorphisms within the gene-encoding enzymes related to alcohol metabolism are associated with levels of serum HDL-cholesterol (HDL-C) in East Asian populations. We evaluated the effects of genetic variants within the aldehyde dehydrogenase-2 (ALDH2) gene and the alcohol dehydrogenase-1B (ADH1B) gene on changes in the lipid profile in an 11-year longitudinal study. We genotyped rs1229984 within ADH1B and rs671 within ALDH2. We combined the genetic data with longitudinal clinical and biochemical data from 2002 to 2013 and designed a retrospective longitudinal study of 1436 Japanese males. There were significant negative relationships between rs671 within ALDH2 and HDL-C levels according to multiple linear regression analysis. Next, we assessed the association between the development of hypo-HDL cholesterolemia and rs1229984 within ADH1B or rs671 within ALDH2. In logistic regression analysis, rs671 A allele homozygote carriers have 2.65 times higher risk of developing hypo-HDL cholesterolemia than G allele homozygote carriers. Even after adjusting for possible confounding factors, a significant association was observed. However, no association between rs1229984 within ADH1B and the development of hypo-HDL cholesterolemia was observed. Rs671 within ALDH2 but not rs1229984 within ADH1B was associated with lower HDL-C levels in Japanese males.

KEYWORDS:

Alcohol dehydrogenase-1B; Aldehyde dehydrogenase-2; Epidemiological study; High-density lipoprotein; Single nucleotide polymorphisms

PMID:
30334266
DOI:
10.1002/lipd.12087
[Indexed for MEDLINE]

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