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Front Cell Neurosci. 2018 Oct 2;12:337. doi: 10.3389/fncel.2018.00337. eCollection 2018.

VGLUT2 Functions as a Differential Marker for Hippocampal Output Neurons.

Author information

1
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
2
Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
3
Berlin Institute of Health, Berlin, Germany.
4
German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
5
NeuroCure - Cluster of Excellence, Charité - Universitätsmedizin Berlin, Berlin, Germany.
6
Einstein Center for Neurosciences, Berlin, Germany.

Abstract

The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

KEYWORDS:

VGLUT2; channelrhodopsin-2; entorhinal cortex; hippocampus; subiculum; synaptic transmission

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