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Intern Med. 2019 Mar 15;58(6):821-825. doi: 10.2169/internalmedicine.1698-18. Epub 2018 Oct 17.

Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency.

Author information

1
Department of Nephrology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
2
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Japan.

Abstract

A 68-year-old man with type 2 diabetes mellitus and chronic hepatitis B infection was referred to the nephrology department before planned surgery for hepatocellular carcinoma. He had been receiving low-dose adefovir dipivoxil (ADV) for 11 years. Laboratory findings revealed impaired re-absorption in the proximal renal tubules. He had been diagnosed with diabetic kidney disease and osteomalacia due to vitamin D deficiency; thus, ADV was not discontinued until he was referred to us. In this case, concomitant diabetes mellitus and vitamin D deficiency might have prevented the early diagnosis of ADV-induced Fanconi syndrome.

KEYWORDS:

Fanconi syndrome; adefovir; diabetic kidney disease; osteomalacia; vitamin D deficiency

PMID:
30333420
PMCID:
PMC6465005
DOI:
10.2169/internalmedicine.1698-18
[Indexed for MEDLINE]
Free PMC Article

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