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J Virol. 1987 May;61(5):1743-6.

Replication of latent Epstein-Barr virus genomes in Raji cells.

Abstract

The replication of the 50 to 60 latent, predominantly extrachromosomal, Epstein-Barr virus genomes maintained by the Burkitt-lymphoma-derived Raji cell line was investigated by using a Meselson-Stahl density transfer approach. Samples of DNA isolated from cells cultivated for different periods in bromodeoxyuridine-supplemented medium were fractionated according to density, and the distribution of viral and cellular DNAs among the heavy-, hybrid-, and light-density species was quantitated. The results indicate that the majority of latent Epstein-Barr virus DNA plasmids each replicate once during the cell cycle.

PMID:
3033303
PMCID:
PMC254169
[Indexed for MEDLINE]
Free PMC Article
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