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Cell Rep. 2018 Oct 16;25(3):640-650.e2. doi: 10.1016/j.celrep.2018.09.064.

Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1.

Author information

1
James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany. Electronic address: alessio_attardo@psych.mpg.de.
2
James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA 94305, USA.
3
Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
4
Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; CREST-AMED, Chiyoda-ku, Tokyo 100-0004, Japan.
5
James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA. Electronic address: mschnitz@stanford.edu.

Abstract

Neural network remodeling underpins the ability to remember life experiences, but little is known about the long-term plasticity of neural populations. To study how the brain encodes episodic events, we used time-lapse two-photon microscopy and a fluorescent reporter of neural plasticity based on an enhanced form of the synaptic activity-responsive element (E-SARE) within the Arc promoter to track thousands of CA1 hippocampal pyramidal cells over weeks in mice that repeatedly encountered different environments. Each environment evokes characteristic patterns of ensemble neural plasticity, but with each encounter, the set of activated cells gradually evolves. After repeated exposures, the plasticity patterns evoked by an individual environment progressively stabilize. Compared with young adults, plasticity patterns in aged mice are less specific to individual environments and less stable across repeat experiences. Long-term consolidation of hippocampal plasticity patterns may support long-term memory formation, whereas weaker consolidation in aged subjects might reflect declining memory function.

KEYWORDS:

aging; hippocampus; immediate-early genes; plasticity; representations; two-photon imaging

PMID:
30332644
DOI:
10.1016/j.celrep.2018.09.064
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