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Diabetes Res Clin Pract. 2019 Jan;147:76-80. doi: 10.1016/j.diabres.2018.10.005. Epub 2018 Oct 15.

Continuous glucose monitoring use and glucose variability in pre-school children with type 1 diabetes.

Author information

1
Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, University Medical Centre, Ljubljana, Slovenia; Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
2
Faculty of Medicine and Surgery, University of Udine, Udine, Italy.
3
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
4
University Clinic of Respiratory and Allergic Diseases Golnik, Kranj, Slovenia.
5
Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, University Medical Centre, Ljubljana, Slovenia.
6
Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, University Medical Centre, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address: tadej.battelino@mf.uni-lj.si.

Abstract

AIMS:

The objective of this nationwide population-based cohort study was to evaluate the correlation between continuous glucose monitoring (CGM) use and glucose variability in pre-schoolers with type 1 diabetes.

METHODS:

We analysed data from the Slovenian National Registry. The primary endpoint was the difference in glucose variability between periods, during which participants were using CGM and periods, during which CGM was not used, over 5 years.

RESULTS:

A total of 40 children <8 years old were followed for an estimated observational period of 116 patient/years. Mean age at CGM initiation was 3.5 (±1.7) years. Both standard deviation of mean glucose [3.6 mmol/L (3.2-3.9) with CGM and 4.3 mmol/L (3.8-4.7) without CGM, p < 0.001] and coefficient of variation [44.0% (40.4-47.0) with CGM and 46.1% (42.3-49.4) without CGM, p = 0.021] were lower during the periods, when CGM was used. Frequent CGM use (>5 days/week) was associated with a 0.4% [4.4 mmol/mol] reduction in glycated haemoglobin level (7.6% compared to 7.2%, p = 0.047).

CONCLUSIONS:

Our results indicate that the use of CGM was associated with reduced glucose variability during a 5 year follow-up period among pre-schoolers with type 1 diabetes.

TRIAL REGISTRATION:

Clinicaltrials.gov: NCT-03293082.

KEYWORDS:

Children; Continuous glucose monitoring; Insulin therapy; Type 1 Diabetes

PMID:
30332618
DOI:
10.1016/j.diabres.2018.10.005
[Indexed for MEDLINE]
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