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Prenat Diagn. 2018 Dec;38(13):1042-1048. doi: 10.1002/pd.5374. Epub 2018 Nov 6.

Fetuses with single ventricle congenital heart disease manifest impairment of regional brain growth.

Author information

1
Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California.
2
Rudi Schulte Research Institute, Santa Barbara, California.
3
Department of Pediatrics, Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, California.
4
Keck University School of Medicine, University of Southern California, Los Angeles, California.
5
Department of Biomedical Engineering, University of Southern California, Los Angeles, California.
6
Department of Pediatric Radiology, Children's Hospital Pittsburgh of UPMC, Pittsburgh, Pennsylvania.
7
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
8
Department of Pediatrics, Division of Neonatology, Children's Hospital Los Angeles, Los Angeles, California.

Abstract

OBJECTIVE:

Anomalous neurological development associated with congenital heart disease (CHD) has been reported as early as third trimester of fetal development. While several studies have characterized variations in CHD neurodevelopmental outcomes in early childhood, these reports are often confounded by postnatal factors such as surgical outcome. Recent studies have focused on the comparing neurological variations between fetuses with CHD and normal controls. In this work, we present a comparison of in utero variations in brain development between fetuses with different types of CHD, by analyzing them under categories of single ventricle versus biventricular cardiac anatomy.

METHODS:

Using recent advances in fetal magnetic resonance imaging (MRI), we quantify the volumetric trajectories of various brain tissues (such as cortical plate, developing white matter, cerebrospinal fluid [CSF], and cerebellum).

RESULTS:

Our study is the first to differentiate between intraventricular and extra-axial CSF thereby allowing us to better identify variations in brain composition of the fetuses.

CONCLUSIONS:

Overall, our findings show that while total brain volume is similar between fetuses with single and biventricular anatomy, they exhibit statistically significant disparity in brain composition.

PMID:
30328635
DOI:
10.1002/pd.5374

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