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Influenza Other Respir Viruses. 2019 Mar;13(2):176-183. doi: 10.1111/irv.12615. Epub 2019 Jan 4.

Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial.

Author information

1
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
2
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
3
Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
4
Department of International Cooperation, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
5
St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
6
Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Abstract

BACKGROUND:

It is uncertain whether vitamin D can reduce respiratory infection.

OBJECTIVE:

To determine whether vitamin D supplementation reduces influenza and other upper viral respiratory tract infections.

METHODS:

A total of 1300 healthy children and adolescents between the ages of 3 and 17 years were randomized to vitamin D (14 000 U weekly) or placebo for 8 months in Vietnam. The primary outcome was reverse transcriptase (RT)-PCR-confirmed influenza infection, and the coprimary outcome was multiplex PCR-confirmed non-influenza respiratory viruses. Participants, caregivers, and those assessing outcomes were blinded to group assignment.

RESULTS:

A total of 650 children and adolescents were randomly assigned to vitamin D and 650 to placebo. The mean baseline serum 25-hydroxyvitamin D levels were 65.7 nmol/L and 65.2 nmol/L in the intervention and placebo groups, respectively, with an increase to 91.8 nmol/L in the vitamin D group and no increase, 64.5 nmol/L, in the placebo group. All 1300 participants randomized contributed to the analysis. We observed RT-PCR-confirmed influenza A or B occurred in 50 children (7.7%) in the vitamin D group and in 43 (6.6%) in the placebo group (hazard ratio [HR]: 1.18, 95% CI: 0.79-1.78). RT-PCR-confirmed non-influenza respiratory virus infection occurred in 146 (22.5%) in the vitamin D group and in 185 (28.5%) in the placebo group (hazard ratio [HR]: 0.76, 95% CI: 0.61-0.94). When considering all respiratory viruses, including influenza, the effect of vitamin D in reducing infection was significant, HR: 0.81, 95% CI: 0.66-0.99.

CONCLUSION:

Vitamin D supplementation did not reduce the incidence of influenza but moderately reduced non-influenza respiratory viral infection.

KEYWORDS:

influenza; randomized trial; respiratory viruses; vitamin D

PMID:
30328294
PMCID:
PMC6379634
DOI:
10.1111/irv.12615
[Indexed for MEDLINE]
Free PMC Article

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