Format

Send to

Choose Destination
Clin Rheumatol. 2018 Dec;37(12):3239-3246. doi: 10.1007/s10067-018-4318-5. Epub 2018 Oct 16.

Telomere dysfunction-related serological markers and oxidative stress markers in rheumatoid arthritis patients: correlation with diseases activity.

Author information

1
Rheumatology and Rehabilitation Department, Assiut University Hospitals, Faculty of Medicine, Assiut, Egypt. drraniami@gmail.com.
2
Rheumatology and Rehabilitation Department, Assiut University Hospitals, Faculty of Medicine, Assiut, Egypt.
3
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
4
Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
5
Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
6
Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University Hospital, Cairo, Egypt.
7
Clinical pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
8
Department of Medicine, Division of Rheumatology, University of California in Los Angeles (emeritus), Los Angeles, CA, USA.
9
Department of Rheumatology, Division of Rheumatology, University of Washington, Seattle, WA, USA.
10
Division of Rheumatology and Experimental Medicine, University of Florence, Florence, Italy.

Abstract

Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis with progressive destruction of the synovial joints associated with systemic manifestations. RA is characterized by infiltration of the synovial joints with inflammatory immune cells with premature immunosenescence. Shorter telomere length in the peripheral blood cells and increase in the oxidative stress have been detected in patients with RA. The aim of the present study was to study the association of markers of telomere shortening and oxidative stress with RA disease activity. Sixty-one RA patients and 15 healthy controls were enrolled in the study. Demographic data, clinical examination, and disease activity status were evaluated for the RA patients. Serum levels of chitinase and NAG (telomere markers) were determined by biochemical reactions using colloidal chitin and NAG as substrates, respectively. Nitric oxide and superoxide dismutase (oxidative stress markers) were determined colometrically and spectrophotometrically, respectively, in the sera of RA patients and controls. Results were correlated with disease activity. Indices of telomere shortening and oxidative markers were significantly higher in RA patients compared to controls. These indices were correlated with signs of disease activity (including number of swollen and tender joints, DAS-28, and inflammatory markers). Rheumatoid arthritis is a disease in which markers of telomere shortening and elevated oxidant stress correlate with disease activity.

KEYWORDS:

Disease activity; Oxidative stress; Rheumatoid arthritis; Telomere dysfunction

PMID:
30328024
DOI:
10.1007/s10067-018-4318-5

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center