Format

Send to

Choose Destination
Surgery. 2019 Jan;165(1):242-249. doi: 10.1016/j.surg.2018.03.026. Epub 2018 Oct 14.

The devil is in the details: Assessing treatment and outcomes of 6,795 patients undergoing remedial parathyroidectomy in the Collaborative Endocrine Surgery Quality Improvement Program.

Author information

1
Department of Surgery, Duke University Medical Center, Durham, NC. Electronic address: hadiza.kazaure@duke.edu.
2
Duke University, Department of Biostatistics and Bioinformatics, Durham, NC.
3
Department of Surgery, Duke University Medical Center, Durham, NC.

Abstract

BACKGROUND:

Multi-institutional data describing remedial parathyroidectomy compared with index parathyroidectomy are scarce.

METHODS:

Using data in the Collaborative Endocrine Surgery Quality Improvement Program (2014-2017), baseline characteristics and outcomes of patients undergoing remedial parathyroidectomy versus index parathyroidectomy were examined using bivariate and multivariate methods. Rates of hypercalcemia and hypocalcemia at ≥ 180 days were assessed.

RESULTS:

Among 6,795 patients, 367 (5.4%) underwent remedial parathyroidectomy. A single localization study was done in 24.8% versus 26.9% of remedial parathyroidectomy versus index parathyroidectomy (P = .37). Patients undergoing remedial parathyroidectomy had higher rates of preoperative laryngoscopy (45.5% versus 6.2%, P < .001), intraoperative nerve monitoring (57.5% versus 34.5%, P < .001), and < 50% drop in hyperparathyroidism than those undergoing index parathyroidectomy (9.6% versus 3.3%, P < .001). Among patients with ≥ 180 days follow-up, none of the remedial parathyroidectomy versus three index parathyroidectomy patients (0.3%) had vocal cord dysfunction. Hypercalcemia rates for remedial parathyroidectomy and index parathyroidectomy were 10.5% versus 5.0 (P = .07), and hypocalcemia rates were 10.5% versus 2.4% (P < .001). After multivariate adjustment, failure to cure was 4.0 times more likely in remedial parathyroidectomy than index parathyroidectomy (P < .001).

CONCLUSION:

This is the first multi-institutional examination of remedial parathyroidectomy outcomes in the Collaborative Endocrine Surgery Quality Improvement Program. Nerve injury rates are low; high rates of hypercalcemia and hypocalcemia suggest potential opportunities to refine the preoperative and intraoperative management of patients undergoing remedial parathyroidectomy.

PMID:
30327186
DOI:
10.1016/j.surg.2018.03.026

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center