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Pancreas. 2018 Nov/Dec;47(10):1239-1243. doi: 10.1097/MPA.0000000000001168.

Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Author information

1
Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
2
Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, IN.
3
Section of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX.
4
Departments of Pediatrics and Surgery, University of Minnesota Medical School, Minneapolis, MN.
5
Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH.
6
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX.
7
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
8
Departments of Medicine, and Biochemistry and Molecular Biology, Indiana University School of Medicine, the Melvin and Bren Simon Cancer Center, and the Pancreatic Cancer Signature Center, Indianapolis, IN.
9
Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN.
10
Department of Surgery, University of Auckland, Auckland, New Zealand.
11
Departments of Medicine, Cell Biology and Molecular Physiology, and Human Genetics, University of Pittsburgh, and UPMC.
12
Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA.
13
Cancer Biomarker Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD.
14
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Abstract

Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, "Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study," that seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions after a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.

PMID:
30325863
PMCID:
PMC6195331
[Available on 2019-11-01]
DOI:
10.1097/MPA.0000000000001168
[Indexed for MEDLINE]

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