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Pancreas. 2018 Nov/Dec;47(10):1229-1238. doi: 10.1097/MPA.0000000000001170.

PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies: Rationale and Study Design for PROCEED From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Author information

1
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA.
2
Digestive and Liver Disorders, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
3
Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX.
4
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.
5
Biostatistics Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
6
Division of General Surgery, Baylor College of Medicine, Houston, TX.
7
Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL.
8
Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
9
Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH.
10
Department of Surgery, University of Florida, Gainesville, FL.
11
Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX.
12
Cancer Biomarker Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD.
13
Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA.
14
Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.
15
Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
16
Division of Research, Kaiser Permanente Northern California, Oakland, CA.

Abstract

Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP. In addition to collecting detailed information using structured case report forms and protocol-mandated evaluations at baseline and during follow-up, PROCEED will establish a linked biorepository of blood, urine, saliva, stool, pancreatic fluid, and pancreatic tissue. Enrollment for PROCEED began in June 2017. As of July 1, 2018, nine clinical centers of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer are enrolling, and 350 subjects have completed baseline evaluation. In conclusion, PROCEED will provide the most accurate and reliable estimates to date on progression of CP. The established cohort and biorepository will facilitate numerous analyses, leading to new strategies for diagnosis, methods to monitor disease progression, and treatment of CP.

PMID:
30325862
DOI:
10.1097/MPA.0000000000001170
[Indexed for MEDLINE]

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