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Pancreas. 2018 Nov/Dec;47(10):1222-1228. doi: 10.1097/MPA.0000000000001172.

INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Author information

1
Department of Pediatrics, University of California San Francisco, San Francisco, CA.
2
Department of Pediatrics, University of Utah, Salt Lake City, UT.
3
Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA.
4
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
5
Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX.
6
Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN.
7
Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA.
8
Department of Pediatrics, Baylor College of Medicine, Houston, TX.
9
Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
10
Department of Pediatrics, Seattle Children's Hospital, Seattle, WA.
11
Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.
12
Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
13
Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN.
14
Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, Canada.
15
Department of Pediatrics and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
16
Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
17
Department of Pediatrics, School of Women's and Children's Health, Medicine, University of New South Wales and Sydney Children's Hospital, Sydney, Australia.
18
Department of Pediatrics, Stanford University, Stanford, CA.
19
Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD.
20
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.
21
Department of Pediatrics, Hadassah Hebrew University Hospital, Jerusalem, Israel.
22
Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA.
23
Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX.
24
Department of Pediatrics, Washington University School of Medicine, St Louis, MO.

Abstract

We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes.Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.

PMID:
30325861
PMCID:
PMC6195325
[Available on 2019-11-01]
DOI:
10.1097/MPA.0000000000001172

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