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Pancreas. 2018 Nov/Dec;47(10):1200-1207. doi: 10.1097/MPA.0000000000001174.

Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Chronic Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Author information

1
Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
2
Departments of Epidemiology, Neurology, and Anesthesia, University of Pennsylvania Philadelphia, PA.
3
Mission: Cure, Chicago, IL.
4
Department of Medicine, Stanford University Stanford, CA.
5
Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA.
6
Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX.
7
Department of Medicine II, Ludwig Maximilians University and Polyklinik, Munich, Germany.
8
Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
9
Division of Gastroenterology, Stead Family Department of Pediatrics, University of Iowa School of Medicine, Iowa City, IA.
10
Division of Gastroenterology, University of Pittsburgh, Pittsburgh, PA.

Abstract

The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP.

PMID:
30325858
PMCID:
PMC6196743
[Available on 2019-11-01]
DOI:
10.1097/MPA.0000000000001174

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