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Methods Mol Biol. 2018;1863:281-301. doi: 10.1007/978-1-4939-8772-6_16.

Modelling Time-Dependent Acquisition of Positional Information.

Author information

1
McGill University, Ernest Rutherford Physics Building, 3600 rue University, H3A2T8, Montreal, QC, Canada.

Abstract

Theoretical and computational modelling are crucial to understand dynamics of embryonic development. In this tutorial chapter, we describe two models of gene networks performing time-dependent acquisition of positional information under control of a dynamic morphogen: a toy-model of a bistable gene under control of a morphogen, allowing for the numerical computation of a simple Waddington's epigenetic landscape, and a recently published model of gap genes in Tribolium under control of multiple enhancers. We present detailed commented implementations of the models using python and jupyter notebooks.

KEYWORDS:

Modelling; Multistability; Ordinary differential equations; Positional information; Python; Seg-mentation

PMID:
30324604
DOI:
10.1007/978-1-4939-8772-6_16
[Indexed for MEDLINE]

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