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Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01801-18. doi: 10.1128/AAC.01801-18. Print 2019 Jan.

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

Author information

1
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA mrj6@case.edu robert.bonomo@va.gov.
2
Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
3
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
4
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
5
Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
6
Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
7
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
8
Public Health Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
9
J. Craig Venter Institute, Rockville, Maryland, USA.
10
Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA mrj6@case.edu robert.bonomo@va.gov.
11
Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.
12
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.
13
Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA.
14
Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA.
15
CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case Virginia, USA CARES), Cleveland, Ohio, USA.

Abstract

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.

KEYWORDS:

Enterobacteriaceae ; Gram-negative bacteria; S-649266; cefiderocol; cephalosporin; siderophore

PMID:
30323050
PMCID:
PMC6325197
[Available on 2019-06-21]
DOI:
10.1128/AAC.01801-18

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