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Blood. 2018 Dec 13;132(24):2580-2593. doi: 10.1182/blood-2018-06-856831. Epub 2018 Oct 15.

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia.

Liao C1,2,3, Prabhu KS1,2,3,4, Paulson RF1,2,3,4.

Author information

1
Pathobiology Graduate Program.
2
Department of Veterinary and Biomedical Sciences.
3
The Center for Molecular Immunology and Infectious Disease, and.
4
The Penn State Cancer Institute, Pennsylvania State University, University Park, PA.

Abstract

Anemic stress induces a physiological response that includes the rapid production of new erythrocytes. This process is referred to as stress erythropoiesis. It is best understood in the mouse where it is extramedullary and utilizes signals and progenitor cells that are distinct from bone marrow steady-state erythropoiesis. The development of stress erythroid progenitors occurs in close association with the splenic stress erythropoiesis niche. In particular, macrophages in the niche are required for proper stress erythropoiesis. Here we show that the expansion of the niche occurs in concert with the proliferation and differentiation of stress erythroid progenitors. Using lineage tracing analysis in 2 models of anemic stress, we show that the expansion of the splenic niche is due to the recruitment of monocytes into the spleen, which develop into macrophages that form erythroblastic islands. The influx in monocytes into the spleen depends in part on Ccr2-dependent signaling mediated by Ccl2 and other ligands expressed by spleen resident red pulp macrophages. Overall, these data demonstrate the dynamic nature of the spleen niche, which rapidly expands in concert with the stress erythroid progenitors to coordinate the production of new erythrocytes in response to anemic stress.

PMID:
30322871
PMCID:
PMC6293871
[Available on 2019-12-13]
DOI:
10.1182/blood-2018-06-856831

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