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Med Gas Res. 2018 Sep 25;8(3):103-110. doi: 10.4103/2045-9912.241075. eCollection 2018 Jul-Sep.

Clinical utility of ozone therapy for musculoskeletal disorders.

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Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY, USA.
Foley Plaza Medical, New York, NY, USA.
Medical Student Research Institute, St. George's University School of Medicine, Grenada, West Indies.
Department of Urology, Stony Brook University School of Medicine, Stony Brook, NY, USA.


Oxygen-ozone (O3) therapy serves as an alternative medical technique that increases the oxygen in the body along with the introduction of O3. O3 therapy has finally reached a level where the biological mechanisms of action have been understood, showing that they are in the domain of physiology, biochemistry, and pharmacology. Few clinical applications have been reviewed here as well as exemplifying that O3 therapy is particularly useful in musculoskeletal disorders. In the therapeutic range, O3 can be used as a more effective and safe substitute of standard medications. O3 therapy has been used for many years for its ability to inactivate various viruses, cancer, and acquired immune deficiency syndrome but is now making strides in the treatment of musculoskeletal disorders such as rheumatoid arthritis, lumbar facet joint syndrome, subacromial bursitis, carpal tunnel syndrome, osteoarthritis, hip bursitis, shoulder adhesive capsulitis, herniated disc, and temporomandibular joint disorder.


carpal tunnel syndrome; cervical disc herniation; fibromyalgia; herniated disc; lumbar facet syndrome; muscle oxygenation; osteoarthritis; oxygen-ozone therapy

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Conflicts of interest The authors have no conflicts of interests to declare.

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