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Expert Opin Ther Targets. 2018 Nov;22(11):893-898. doi: 10.1080/14728222.2018.1536748. Epub 2018 Oct 17.

The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia.

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a Center for Regenerative Medicine, Massachusetts General Hospital , Boston and Harvard Stem Cell Institute , Cambridge , MA , USA.


Acute myeloid leukemia; Brequinar; DHODH; differentiation; metabolism; nucleotides; pyrimidines; therapeutic window

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