Format

Send to

Choose Destination
Acad Radiol. 2018 Oct 12. pii: S1076-6332(18)30438-0. doi: 10.1016/j.acra.2018.09.015. [Epub ahead of print]

Utility of 13N-Ammonia PET/CT to Detect Pituitary Tissue in Patients with Pituitary Adenomas.

Author information

1
Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
2
Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
3
Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
4
Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: wanghaij@mail.sysu.edu.cn.

Abstract

RATIONALE AND OBJECTIVES:

It is clinically essential, but sometimes challenging, to distinguish pituitary tissue from pituitary adenomas (PAs). It is helpful to avoid damage of pituitary tissue during management. We evaluated the ability of 13N-ammonia positron emission tomography (PET)/computed tomography (CT) to locate and distinguish pituitary tissue from PAs.

MATERIALS AND METHODS:

Forty-eight patients (four with prolactinoma, 10 with Cushing's disease, 12 with acromegaly, and 22 with nonfunctional PAs) prospectively underwent magnetic resonance imaging (MRI), 13N-ammonia PET/CT, 18F-FDG PET/CT, prior to surgery.

RESULTS:

Pituitary position could be determined in 31 (64.5%) patients by 13N-ammonia PET/CT, and by MRI in 26 (54.2%) patients. It was detected by 13N-ammonia PET/CT and MRI in eight of eight patients (100%) with pituitary microadenoma, tumor maximum diameter (TMD) <1cm, and in nine of 10 patients (90%) with PAs with TMD ≥1cm, but <2cm. In 16 patients with PAs with TMD ≥2cm, but <3cm, pituitary tissue position was detected by 13N-ammonia PET/CT in nine (56%), and by MRI in 8 (50.0%) patients by MRI. In 14 patients with PAs with TMD ≥3cm, pituitary tissue position was detected by 13N-ammonia PET/CT in five (35.7%) patient, and by MRI in 1 (7.1%). In seven patients, the pituitary tissue could be detected by 13N-ammonia PET, but not by MRI, and in two patients by MRI, but not by 13N-ammonia PET.

CONCLUSION:

13N-ammonia PET/CT imaging is a sensitive means for locating and distinguishing pituitary tissue from PAs, particularly those with TMD <2cm. It is potentially valuable in detection of pituitary tissue in patients with PAs.

KEYWORDS:

(13)N-ammonia; (18)F-FDG; Pituitary adenoma; Pituitary tissue; Positron-emission tomography/Computed tomography (PET/CT)

PMID:
30318288
DOI:
10.1016/j.acra.2018.09.015
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center