Format

Send to

Choose Destination
Eur J Pharm Sci. 2019 Jan 15;127:1-8. doi: 10.1016/j.ejps.2018.10.010. Epub 2018 Oct 11.

Diabetic skin and UV light: Protection by antioxidants.

Author information

1
National and Kapodistrian University of Athens, School of Health Sciences, Department of Pharmacy, Section of Pharmaceutical Technology, Panepistimiopolis Zografou, 15784 Athens, Greece.
2
Athens Naval Hospital, Pathologoanatomic Laboratory, 11521 Athens, Greece.
3
National and Kapodistrian University of Athens, School of Health Sciences, Department of Pharmacy, Section of Pharmacognosy and Chemistry of Natural Products, Panepistimiopolis Zografou, 15784 Athens, Greece.
4
National and Kapodistrian University of Athens, School of Health Sciences, Department of Pharmacy, Section of Pharmaceutical Technology, Panepistimiopolis Zografou, 15784 Athens, Greece. Electronic address: rallis@pharm.uoa.gr.

Abstract

Non-invasive biophysical methods were used to study the effect of antioxidant gels, which were prepared from Pinus halepensis bark extracts, vitamin C and water, on the skin of diabetic hairless mice irradiated with UV radiation of 1 and 2 minimal erythemal doses (MEDs). The calculated transepidermal water loss (TEWL) for diabetic mice was found to be fivefold higher on day 11 after irradiation, and in all cases, the TEWL values converged to their initial values on day 21. Both pinus and vitamin C gels inhibited the dehydration of the skin, while water gels did not show similar protection. At low dose of UV-irradiation (1 MED), vitamin C gels showed the best hydration, while by doubling the UV dose, pinus gels induced significant skin-protective effects. Upon irradiation, the mice treatment with pinus gel showed diminished inflammation in comparison with the other gels. Pinus also inhibited the hyperkeratosis of skin. As expected, 2 MEDs caused greater skin damage, such as inflammation, dryness, oxidative stress and rides (aging) compared to the damage induced by 1 MED.

KEYWORDS:

Antioxidants; Dehydration; Diabetes; Mouse; Skin; UV radiation

PMID:
30316976
DOI:
10.1016/j.ejps.2018.10.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center