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J Formos Med Assoc. 2018 Oct 10. pii: S0929-6646(18)30264-X. doi: 10.1016/j.jfma.2018.09.017. [Epub ahead of print]

Melatonin and their analogs as a potential use in the management of Neuropathic pain.

Author information

1
Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan.
2
Planning and Management Office, Tri-Service General Hospital, National Defense Medical Center, Taiwan.
3
Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan; Planning and Management Office, Tri-Service General Hospital, National Defense Medical Center, Taiwan; Institute of Medical Sciences, National Defense Medical Center, Taiwan; Department of Anesthesiology, Tri-Service General Hospital, Taiwan. Electronic address: w82556@gmail.com.

Abstract

Melatonin (N-acetyl-5-methoxytryptamine), secreted by the pineal gland is known to perform multiple functions including, antioxidant, anti-hypertensive, anti-cancerous, immunomodulatory, sedative and tranquilizing functions. Melatonin is also known to be involved in the regulation of body mass index, control the gastrointestinal system and play an important role in cardioprotection, thermoregulation, and reproduction. Recently, several studies have reported the efficacy of Melatonin in treating various pain syndromes. The current paper reviews the studies on Melatonin and its analogs, particularly in Neuropathic pain. Here, we first briefly summarized research in preclinical studies showing the possible mechanisms through which Melatonin and its analogs induce analgesia in Neuropathic pain. Second, we reviewed research indicating the role of Melatonin in attenuating analgesic tolerance. Finally, we discussed the recent studies that reported novel Melatonin agonists, which were proven to be effective in treating Neuropathic pain.

KEYWORDS:

MT2 agonists; Melatonin; Neuropathic pain; Tolerance

PMID:
30316678
DOI:
10.1016/j.jfma.2018.09.017
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