Format

Send to

Choose Destination
Int Immunopharmacol. 2018 Dec;65:140-147. doi: 10.1016/j.intimp.2018.09.019. Epub 2018 Oct 10.

Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-κB in mice.

Author information

1
Department of Physiology, Medical College of Nanchang University, Nanchang University, Nanchang 330006, PR China.
2
Institute of Life Science, Nanchang University, Nanchang 330031, PR China.
3
Department of Physiology, Medical College of Nanchang University, Nanchang University, Nanchang 330006, PR China. Electronic address: zhangdalei@ncu.edu.cn.

Abstract

Perfluorooctane sulfonate (PFOS), a persistent organic pollutant, has been demonstrated to cause multiple toxicities. In this study, we explored the role of naringin (Nar) in alleviating PFOS-caused mouse liver injury and its potential mechanisms. Male mice were intragastrically administered PFOS (10 mg/kg/day) alone or with Nar (100 mg/kg/day) for 3 weeks. Nar supplementation led to resumption of elevated serum hepatic enzyme activities and increased relative liver weight in PFOS-challenged mice. Moreover, Nar treatment increased hepatic expression of transcription factor NRF2 protein and its regulated antioxidative enzyme genes heme oxygenase‑1, superoxide dismutase and catalase, with an inhibition of malondialdehyde and hydrogen peroxide production. Furthermore, simultaneous administration of Nar suppressed PFOS-induced elevation in NF-κB activity and generation of inflammatory cytokines TNF-α and IL-6 in the liver. In addition, Nar enhanced anti-apoptotic Bcl-2 expression, decreased pro-apoptotic Bax expression and inhibited caspase‑3 activation in liver tissue in mice exposed to PFOS. Our results indicate that Nar protects against PFOS-induced hepatotoxicity in mice via modulating oxidative, inflammatory and apoptotic pathways.

KEYWORDS:

Apoptosis; Hepatotoxicity; Inflammation; Naringin; Oxidative stress; Perfluorooctane sulfonate

PMID:
30316072
DOI:
10.1016/j.intimp.2018.09.019
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center