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Adv Exp Med Biol. 2018;1097:261-278. doi: 10.1007/978-3-319-96445-4_14.

Blood-Brain Barrier Integrity and Clearance of Amyloid-β from the BBB.

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Department of Biomedical Engineering, University of North Texas, Denton, TX, USA.
Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Fujian Sheng, China.
Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Department of Biomedical Engineering, The City College of the City University of New York, New York, NY, USA.
Department of Biomedical Engineering, University of North Texas, Denton, TX, USA.


Alzheimer's disease, a type of dementia, affects memory, behavior, and cognitive processes in affected individuals. It is one of the prominent diseases, accounting for 60-80% of dementia cases and affecting a significant population of persons over the age of 65 years. While rare, Alzheimer's disease (AD) may affect the younger population as well. With such a widespread number of persons affected with AD, scientists have undertaken the initiative to develop a cure for this devastating disease; however, it has been deemed quite challenging. A dysfunctional blood-brain barrier, with impaired ability to clear amyloid-β from the brain, has been directly linked to the development of Alzheimer's disease. The blood-brain barrier restricts the flow of many substances into and out of the brain and serves as a selective and protective barrier to the brain. A proper functioning blood-brain barrier contributes to the maintenance and integrity of the brain. In turn, different systems and mechanisms within the blood-brain barrier are set in place to facilitate mediated passage of materials and substances between the brain and the bloodstream. In relation to AD, the mediation of amyloid-β clearance is of great importance in maintaining the blood-brain barrier's integrity.

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