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Am J Geriatr Psychiatry. 2018 Dec;26(12):1268-1272. doi: 10.1016/j.jagp.2018.09.012. Epub 2018 Sep 25.

Gender Differences in Cardiovascular Risk Related to Diabetes and Posttraumatic Stress Disorder.

Author information

1
San Francisco VA Health Care System; University of California, San Francisco. Electronic address: Carolyn.Gibson2@va.gov.
2
San Francisco VA Health Care System; NCIRE-The Veterans Health Research Institute.
3
San Francisco VA Health Care System; University of California, San Francisco.

Abstract

OBJECTIVES:

To examine relationships between posttraumatic stress disorder (PTSD), diabetes, and cardiovascular disease (CVD) among older men and women.

METHODS:

In a national retrospective cohort study of Veterans aged ≥55 (n=2,789,264, 6% female), associations between PTSD and diabetes (2008-2011) and incident CVD (2012-2015) were assessed with gender-stratified Fine-Gray proportional hazard models, adjusted for demographics and medical comorbidities.

RESULTS:

Incident CVD was observed in 22% of men and 12% of women, and related to PTSD (men HR=1.05, 95% CI=1.04-1.06, Wald χ2=80.46, df=1, p<.001; women HR=1.47, 95% CI=1.38-1.57, Wald χ2=148.60, df=1, p<.001), diabetes (men HR=1.34, 95% CI=1.34-1.35, Wald χ2=9177.64, df=1, p<.001; women HR=1.49, 95% CI=1.44-1.55, Wald χ2=419.02, df=1, p<.001), and comorbid PTSD-diabetes (men HR=1.50, 95% CI=1.48-1.52, Wald χ2=4180.92, df=1, p<.001; women HR=1.96, 95% CI=1.80-2.12, Wald χ2=257.28, df=1, p<.001).

CONCLUSIONS:

CVD risk was increased with PTSD and diabetes, and strongly increased with comorbid PTSD-diabetes. Among women, PTSD and diabetes conferred equivalent CVD risk.

KEYWORDS:

Diabetes; cardiovascular; gender; posttraumatic stress disorder

PMID:
30314941
DOI:
10.1016/j.jagp.2018.09.012

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