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J Pediatr. 2019 Jan;204:301-304.e2. doi: 10.1016/j.jpeds.2018.08.033. Epub 2018 Oct 9.

Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials.

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Neonatal Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. Electronic address:
NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
Birmingham Clinical Trials Unit, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
The Royal Women's Hospital, Department of Obstetrics and Gynecology, The University of Melbourne; Murdoch Children's Research Institute Melbourne, Melbourne, Australia.
National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia; Department of Statistics, Macquarie University, Sydney, NSW, Australia.


Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P < .001). This may explain the larger mortality difference seen with revised oximeters. If so, average treatment effects from the Neonatal Oxygen Prospective Meta-analysis trials may be underestimates.


blindness/epidemiology; blindness/etiology; cerebral palsy/epidemiology; enterocolitis, necrotizing/epidemiology; enterocolitis, necrotizing/etiology; humans; incidence; infant; infant mortality; infant, extremely premature; infant, newborn; oximetry; oxygen/administration & dosage; oxygen/adverse effects; oxygen/blood; trial

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